RECENT ADVANCES AND CONTRADICTIONS IN THE STUDY OF THE INDIVIDUAL ROLES OF UBIQUITIN LIGASES THAT REGULATE RIG-I-LIKE RECEPTOR-MEDIATED ANTIVIRAL INNATE IMMUNE RESPONSES

RIG-I and MDA5 are cytoplasmic viral RNA sensors and are essential for antiviral innate immune responses, such as type I interferon production.Post-translational modification is critical for the activation and inactivation of RIG-I and MDA5.At least seven ubiquitin ligases have been reported to be involved in either K63- or K48-linked polyubiquitin

Science, by its method, wants to get truth.Science is a human creation; the truth does not only to fulfill correspondence-coherence criteria of truth, induction-deduction, and empirical-rational thought.The truth and science developing in Indonesia also 2014 dodge ram 1500 fender flares must be back to mankind, Indonesian identity.Pancasila theory

The pervasive effects of the novel coronavirus (COVID-19) have put the world to test.Its effects permeate all facets of life including healthcare services and food supplies.However, most empirical studies failed to investigate its effects on the prices of food and healthcare services, which by all standards, are essential commodities.On this backgr

Abstract Early diagnosis and access to resources, support and therapy are critical for improving long-term outcomes for children with autism spectrum disorder (ASD).ASD is typically detected using a case-finding approach based on symptoms and family history, resulting in many delayed or missed diagnoses.While population-based screening would be ide